As a consequence of the detached helmet, the impact against the ground occurs without any protection, causing the most serious head injuries. Ground contact also accounts for the thoracic injuries. The main head kinase inhibitor Pazopanib injuries highlighted by CT scan (Figure 13) are: right temporal-parietal-occipital multiple fractures,

depressed in the occipital region and diastatic in the mastoid region; diastatic skull base clivus fracture, involving sphenoid bone Inhibitors,research,lifescience,medical body and both carotid channel; right temporal styloid process and right tympanic fracture; right petrous fracture with hemotympanum; pneumocephalus bubbles; lacerated and contused right temporal parietal (2.5 cm) lesions; peri mesencephalic subarachnoid haemorrhage, with relative encephalic pons and mesencephalic hypodensity and widespread cerebral oedema. Figure 13 Head injuries Inhibitors,research,lifescience,medical – impact against the ground. The depressed skull fractures are caused by the www.selleckchem.com/products/nutlin-3a.html direct contact with the ground that has generated a high deformation of the skull. This is due to the minor lateral strength of the skull with respect to its frontal and rear regions [50,51]. A right upper lobe lung contusion and bilateral lower lobe lung contusion in the paravertebral area are Inhibitors,research,lifescience,medical also sustained in the thoracic region (Figure 14). Both injuries are caused by the compression of the lung

at high impact velocity. Figure 14 Thorax injuries – impact against the ground. A summary table with all correlation results and level of reliability in percentage values is shown in

Table 1. Results Twenty-eight serious road accidents occurred between January through July 2011 in the metropolitan area of Florence are included in this study. Demographics of injured The mean age at the time of accident was 34.6 (SD 13.9) (range Inhibitors,research,lifescience,medical 16–70 years) and the people most affected Inhibitors,research,lifescience,medical are between 26 years and 30 years. About 70% of severely injured people are younger than 45 years (Figure 15). Male subjects constituted 83% (n=24) and female subjects 17% (n=5). Figure 15 Age distribution of major trauma in In-SAFE database. PTW riders-and-pillions-passengers are 41% (n=12), car occupants are 31% (n=9), pedestrians 17% (n=5) and cyclists 10% (n=3). Thirty-three percent of PTW occupants (n=4) Batimastat are between 26 and 30 years, 25% (n=3) are between 16 and 20 years. Seventy-five percent (n=6) of the car occupants are drivers with a mean age of 40.5 years (S.D. 15.8). Accident and vehicle configurations The most frequent road users involved in serious accidents are car passengers 49% (n=25) followed by PTW users 25% (n=13), pedestrians 10% (n=5), cyclists 8% (n=4), van passengers 6% (n=3) and buses 2% (n=1). The main road accident configurations that have produced a serious injury are “car to PTW” crashes 25% (n=7), “pedestrian run over” 17,9% (n=5), “car-to-car” 17.9% (n=5), “single vehicle PTW” 10.7% (n=3), “single vehicle car” 7.1% (n=2), “car-to-bicycle” 7.1% (n=2), “van-to-PTW” 7.1% (n=2), “car-to-van” 3.6% (n=1), PTW-to-bicycle” 3.