In addition, there were also some limitations in this study. Firstly, the diagnostic criteria for neonatal hyperbilirubinemia were not consistent. Secondly, there were studies included with a relatively small population of subjects, which might have some effect on the power of our analysis. Thirdly, various other factors may also have contributed to neonatal hyperbilirubinemia, such as environmental factors, which were not explained in
the included studies. The present systematic review with meta-analysis shows that the 388 G>A mutation of the SLCO1B1 gene is a risk factor for developing neonatal hyperbilirubinemia in Chinese neonates, but not in white, learn more Thai, Brazilian, or Malaysian populations; the SLCO1B1 521 T>C mutation provides protection for neonatal hyperbilirubinemia in Chinese neonates, but not in white, Thai, Brazilian or Malaysian neonates. Since other factors involved in neonatal hyperbilirubinemia might impact on the association,
17-AAG further study is needed to assess the effects of genetic variations after adjusting for the effect of other factors. The authors declare no conflicts of interest. “
“In March and April of 2009, casualties from influenza-like illness showed a rise in Mexico and the United States. Caused by a new strain of influenza A (H1N1), it rapidly emerged as the new influenza pandemic, Amylase which caused a considerable number of deaths by respiratory failure throughout the world in the following months.1 and 2 As we entered the post-pandemic period in August 2010, the virus continues to circulate in many countries. In 2011, the World Health Organization
(WHO) standardized the name of the new virus: influenza A(H1N1)pdm09. In Brazil, infections due to influenza A(H1N1)pdm09 are occurring after the first pandemic wave with a seasonal pattern, mainly in the South and Southeast regions, and are still causing several deaths each year, mostly in winter months.3 Although in most pediatric patients the disease is asymptomatic or mild, with self-limited course, a small proportion of patients die, primarily due to respiratory failure.4 and 5 Many respiratory viruses also have seasonality in winter months, and a clinical distinction between influenza A(H1N1)pdm09 and other respiratory viruses is difficult, because the signs and symptoms are not specific.6 As a result, the incidence of cases defined as influenza-like illness is usually much higher than real influenza-associated disease.7 As an additional difficulty, laboratory diagnosis of influenza A(H1N1)pdm09 is problematic in most clinical settings, due to lack of sensitivity of rapid tests and direct immunofluorescence assay (DFA), which are the most available tests.