When compared to melting in a vessel, the product stability and dissolution are similar, but melt extrusion offers the potential to shape the heated drug-matrix mixture into implants, ophthalmic inserts, or oral dosage forms.32 The theoretical approach to understanding the melt extrusion process is therefore, generally presented by dividing the process of flow into four sections are Feeding of the extruder, Conveying of mass (mixing and reduction of particle size), Flow through the die, Exit from the die and down-stream
processing. Lyophilization involves transfer of heat and mass to and from the product under preparation. This technique was proposed as an alternative technique to solvent evaporation. Lyophilization has been thought of a molecular mixing technique where the drug and carrier are co dissolved in a common solvent, frozen and sublimed to obtain a lyophilized molecular dispersion.33 The supercritical Akt inhibitor ic50 fluid antisolvent learn more techniques, carbon dioxide are used as an antisolvent for the solute but as a solvent with respect to the organic solvent. Different acronyms were used by various authors to denote micronization processes: aerosol solvent extraction system, precipitation with a compressed fluid antisolvent, gas
antisolvent, and solution enhanced dispersion by supercritical fluids, and supercritical antisolvent. The SAS process involves the spraying of the solution composed of the solute and of the organic solvent into a continuous supercritical phase flowing concurrently. Use of supercritical carbon dioxide is advantageous as it is much easier to
remove from the polymeric materials when the process is complete, even though a small amount of carbon dioxide remains trapped inside the polymer; it poses no danger to the patient. This technique does not require the use of organic solvents and since CO2 is considered isothipendyl environmentally friendly, this technique is referred to as ‘solvent free’.34 The technique is known as rapid expansion of supercritical solution (RESS). Amorphous solid dispersion is widely used for the preparation of oral poorly water-soluble drugs. This review is mainly explains the preparative methods of dispersion and the characterization. Amorphous solids are minimizes the various disadvantages of the oral drug delivery system. Solubility enhancement of the drugs remains one of the most challenging aspects of drug development in the pharmaceutical field. Various methods are developed for enhancing the solubility and dissolution of the drugs. The amorphous solid dispersion is the one of the most effective approaches to achieve the goal of solubility enhancement of poorly water-soluble drugs. Various methods described for preparation of ASD in lab scale and industrial scale. All authors have none to declare. “
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