The 11 beta-HSD1 is believed to maintain tonic inhibition of the mineralocorticoid receptor in cardiomyocytes, and mineralocorticoid

receptor activation is involved in the pathophysiology of LVH. We assessed the association between polymorphisms in the HSD11B1 gene and left ventricular mass (LVM) in 248 families ascertained through a proband with hypertension.

Methods and Results-LVM was measured by electrocardiography and echocardiography in 868 and 829 participants, PCI 32765 respectively. Single-nucleotide polymorphisms (SNPs) tagging common variation in the HSD11B1 gene were genotyped by mass spectrometry. The rs846910 SNP, which lies in the flanking region 5′ to exon 1B of HSD11B1, was associated with LVM both by electrocardiography (approximate to 5% lower LVM per copy of the rare allele, P = 0.02) and by echocardiography (approximate to 10% lower LVM per copy of the rare allele, P = 0.003). Genotype explained 1% to 2% of the population variability in LVM, or approximately 5% of the heritable fraction. There were no significant

associations this website between any HSD11B1 SNP and blood pressure or body mass index that could have confounded the association with LVM.

Conclusions-Genotype at HSD11B1 has a small, but significant effect on LVM, apparently independently of any effect on obesity-related traits. These findings suggest a novel action of 11 beta-HSD1 in the human cardiomyocyte, which may be of therapeutic importance. (Circ

Cardiovasc Genet. 2011;4:156-162.)”
“Metal-ferroelectric-insulator-semiconductor thin-film capacitors with Pb(Zr-0.6,Ti-0.4)O-3 (PZT) ferroelectric layer and high-k lanthanum oxide (La2O3) insulator layer were fabricated. The outdiffusion of atoms between La2O3 and silicon was examined by the secondary-ion-mass spectroscopy. The size of memory window as a function of PZT annealing temperature was discussed. The maximum memory window saturated to 0.7 V, which is close to the theoretical memory window Delta W approximate to 2d(f)E(c)approximate to 0.8 V with higher annealing temperatures above 700 degrees C. The memory window starts to decrease due to charge injection when the sweep voltage is higher than 5 V at 600 degrees C-annealed samples. The C-V flatband voltage shift (Delta V-FB) as a function of charge injection was characterized in MLN4924 this work. An energy band diagram of the Al/PZT//La2O3/p-Si system was proposed to explain the memory window and the flatband voltage shift.”
“The aim of this study was to evaluate the nematocidal effects of natural phytoregulators jasmonic acid (JA) and methyl-jasmonate (MJ) against plant parasitic nematodes Pratylenchus zeae (Graham) (Pratylenchidae) and Helicotylenchus spp. (Hoplolaimidae). Both JA and MJ promoted elevated percentages of mortality in P. zeae and Helicotylenchus spp. after 12 and 24h of nematodes exposition at different concentrations of jasmonates.