05) in the activities of hexokinase, glucose-6-phosphatase and glucose-6-phosphate dehydrogenase in respect to diabetic control [Figures [Figures22�C4]. Figure 2 Remedial effect of mother tincture of S jambolanum selleck chemicals on hepatic and skeleto muscular hexokinase activity in STZ-induced diabetic rats. Bars represent mean �� S.E.M. (n = 6). Bars with superscripts a, b, c differ from each other significantly at … Figure 4 Activities of Glucose-6-phosphate dehydrogenase in liver and skeleto muscle in STZ-induced diabetic rats after the treatment of S jambolanum. Bars represent mean �� S.E.M. (n = 6). Bars with superscripts a, b, c differ from each other significantly … Figure 3 Protective effect of mother tincture of S jambolanum on hepatic ad skeletal muscular glucose-6-phosphate activity in STZ-induced diabetic rats.
Bars represent mean �� S.E.M. (n = 6). Bars with superscripts a, b, c differ from each other significantly … Serum lipid profile Levels of serum TG, TC, LDLc and VLDLc were increased significantly (P < 0.05) in STZ-induced diabetic group in respect to untreated control. After administration of the homeopathic drug to diabetic group of animals, a significant recovery (P < 0.05) was noted towards the control. In homeopathic drug treated diabetic group of animals, serum HDLc level was resettled towards the control level significantly (P < 0.05) [Table 1]. Table 1 Effect of mother tincture of S jambolanum on serum lipid profiles in STZ-induced diabetic rats Glycogen content Quantity of glycogen in liver and skeletal muscle which was decreased significantly (P < 0.
05) in diabetic group of animals in respect to untreated control was recovered significantly (P < 0.05) after the drug treatment to diabetic animals [Figure 5]. Figure 5 Glycogen level in metabolic tissues (liver and skeletal muscle) in STZ-induced diabetic rats. Bars represent Mean �� SEM (n = 6). Bars with superscripts a, b, c differ from each other significantly, P < 0.05 Levels of glutamate oxaloacetate transaminase, glutamate pyruvate transaminase activities in eerum Activities of GOT, GPT in serum were increased significantly (P < 0.05) in diabetic control group in respect to untreated control group of animals. Significant recoveries (P < 0.05) were observed in the activities of serum GOT and GPT in drug treated diabetic group when comparison was made with diabetic control group [Figure 6].
Figure 6 Levels of serum GOT, GPT activities in STZ-induced diabetic rats. Bars represent Mean �� SEM (n = 6). Bars with superscripts a, b, c differ from each other significantly, P < 0.05 DISCUSSION STZ-induced diabetes causes the partial destruction of ��-cell of the islets Cilengitide which leads to insufficient release of insulin and there by increased blood glucose levels namely hyperglycemia.