Acute exacerbation of chronic HBV infection was defined as an increase of serum alanine aminotransferase (ALT) level more than five times the upper limit of normal. We analyzed

the causes and the clinical course of these patients with acute exacerbation. Results: The most frequent cause of acute exacerbation arised from hepatitis B viral factors; spontaneous reactivation(48.1%) and HBeAg seroconver-sion(10.0%). The next arised from hepatotoxicity; alcohol(8.1%) and drugs including herbal medicines(7.6%). Vemurafenib Accompanying other diseases(12.9%), coinfection by hepatitis A virus(7.2%) or hepatitis D virus(1.9%), the development of hepatocellular carcinoma (HCC)(1.9%), and liver injury(1%) were the Maraviroc mw rest. Spontaneous reactivation of HBV showed the longest period to ALT normalization among the causes of acute exacerbation of which the average duration was 134.5 ± 184.2 days. A total of four patients rapidly deteriorated to fulminant hepatic failure; three of them died, one

transferred to receive liver transplantation. Herbal medicine, alcohol, HCC development and traumatic liver laceration were the causes of liver failure, respectively. Conclusions: The main causes of acute exacerbation in asymptomatic HBV infection were spontaneous reactivation of HBV and HBeAg seroconversion which tented to recover well through antiviral therapy or spontaneously. Otherwise, The greatest care should be taken in managing acute exacerbation of HBV-infected patients by hepatotoxicity or HCC development. Disclosures: The following people have nothing to disclose: Woo Hee Cho, Hyoung Joon Kim, Sun Young Cho, Young Kwang Choo, Sung Soo La, Suk Bae Kim, Il Han Song Background/Aim. Most common occurring HBV variants include precore stop codon (PC) and the dual mutation in basal core promoter region (BCP). We aimed to determine

prevalence of PC and BCP in a multi ethnic chronic hepatitis B population and establish association of these variants with demographical, clinical, virological and histological data. Methods. At inclusion a liver biopsy and a serum sample the same day. Demographical, clinical and biochemical data were collected. HBeAg status [(e+) or (e-)], HBV variants, HBV DNA and HBsAg titers, HBV and IL28B genotypes, histological lesions were determined the day Calpain of liver biopsy. Results: 406 consecutive CHB patients, 101 e(+) and 305 e(-). Wild type (WT), BCP, PC, and BCP+PC found in 18%, 29%, 25% and 28%, respectively. Mean age was 40±12 years, 76% were male, 42% Caucasian, 18% Asian, and 40% Black African. HBV genotype A, B, C, D, and D found in 26%, 11%, 9%; 24%, and 30%, respectively, IL28 genotype CC, TT and CT found in 43%, 26%, and 31%, respectively. Fibrosis stage >F1 found in 39%, Activity grade >1 found in 29%. HBV DNA titers <3.3, 3.3 to 4.3 and >4.3 log IU/ml found in 21%, 20% and 59%, respectively. HBsAg titers <3.3, 3.