Brain Res 2010, 1357:166–174.PubMedCrossRef 13. Swiss VA, Casaccia P: Cell-context specific role of the E2F/Rb pathway in development Pevonedistat and disease. Glia 2010, 58:377–390.PubMed 14. Du W, Searle JS: The rb pathway and cancer therapeutics. Curr Drug Targets 2009, 10:581–589.PubMed 15. Knudsen ES, Wang JY: Targeting the RB-pathway in cancer therapy. Clin Cancer Res 2010, 16:1094–1099.PubMedCrossRef 16. Witkiewicz AK, Knudsen ES: RB pathway and therapeutic sensitivity: New insights in breast cancer and Tamoxifen therapy. Cell Cycle 2011., 10: 17. Comprehensive genomic characterization defines human Smad family glioblastoma genes and core pathways Nature 2008, 455:1061–1068.

18. Pietruszewska W, Klatka J, Borzecki A, Rieske P: Loss of heterozygosity for Rb locus and pRb immunostaining in laryngeal cancer: a clinicopathologic, molecular and immunohistochemical study. Folia Histochem Cytobiol 2008, 46:479–485.PubMedCrossRef 19. Fry DW, Harvey PJ, Keller PR, Elliott WL, Meade M, Trachet E, Albassam M, Zheng Captisol clinical trial X, Leopold WR, Pryer NK, Toogood PL: Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther 2004, 3:1427–1438.PubMed 20. Vaughn DJ, Flaherty K,

Lal P, Gallagher M, O’Dwyer P, Wilner K, Chen I, Schwartz G: Treatment of growing teratoma syndrome. N Engl J Med 2009, 360:423–424.PubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions CK have made substantial contributions to acquisition of data. WY participated in the design of the study and performed the statistical analysis. BX participated in its design and drafted the manuscript. All Sodium butyrate authors read and approved the final manuscript.”
“Introduction More patients with early breast cancer have been diagnosed with the development of screening techniques [1]. Following adjuvant chemotherapy and endocrine therapy can significantly improve disease-free survival (DFS) and overall survival (OS) in early breast cancer patients [2–4]. However, both adjuvant chemotherapy and endocrine therapy cause bone loss to these

patients. Patients with amenorrhea after chemotherapy [5, 6] and postmenopausal patients receiving aromatase inhibitors (AIs) are at high risk of bone loss [3, 4, 7–9]. Zoledronic acid (ZOL) can prevent bone loss in early breast cancer patients [10]. Furthermore, ZOL also has antitumor and antimetastatic properties. The previous meta-analysis [11] suggested that the use of ZOL was associated with a statistically significant lower risk for disease recurrence. In addition, ZOL has several potential advantages compared to the oral bisphosphonates, including good bioavailability, gastrointestinal tolerance, and adequate compliance [12]. Thus, less adverse effects, such as gastrointestinal disorders and vascular disorders, were caused by ZOL [12].