Conclusions: Sacral nerve stimulation is effective in the majority of our patients, and should be considered in children with severe dysfunctional elimination syndrome refractory to maximum medical treatment.”
“Purpose: We investigated the correlations between ultrasonographic bladder wall thickness and urodynamic parameters, and estimated
the diagnostic accuracy of bladder wall thickness for predicting unfavorable urodynamic patterns in children with myelodysplasia.
Materials and Methods: A total of 57 children (median age 5.1 years.) with myelodysplasia were enrolled in the study. All children underwent ultrasonography to measure bladder wall thickness. Videourodynamic evaluation was also performed within 3 months of ultrasound assessment. SRT1720 Bladder wall thickness was compared to urodynamic data. A urodynamic risk of upper urinary tract deterioration was defined as maximum detrusor pressure greater than 40 cm H2O during filling or at leakage, or sphincter dyssynergia during voiding.
Results: Bladder wall thickness was significantly correlated to detrusor leak point pressure, maximum amplitude of detrusor overactivity and maximum detrusor pressure during storage phase. In 16 children who had unfavorable urodynamic risk patterns the mean bladder wall thickness was 3.9 +/- 1.0 mm, compared to 2.4 +/- 0.7 mm. in 41 patients with favorable urodynamic patterns. There was a significant difference
between bladder wall thickness in children with and those without urodynamic risk factors Foretinib (p < 0.001). For a diagnosis INCB018424 cell line of unfavorable urodynamic patterns bladder wall thickness greater than 3.3 mm had a positive predictive value of 85.7%, a negative predictive value of 90.7%, specificity of 75.0% and sensitivity of 95.1%. Receiver operator characteristic analysis revealed that bladder wall
thickness had a high predictive value for unfavorable urodynamic patterns, with an area under the curve of 0.908.
Conclusions: Ultrasonographic assessment of bladder wall thickness is a sensitive screening tool for the diagnosis of urodynamic risk factors for upper urinary tract deterioration in children with myelodysplasia.”
“Purpose: Incidentally detected complex renal cysts in children are a rare but worrisome occurrence due to the perceived potential risk of malignancy. We examined the natural history of such cysts in a cohort of children.
Materials and Methods: We obtained access to a database containing all radiology reports generated at a single institution from 1996 to 2004. We used key words to limit our search, subsequently reviewing charts and images to confirm the diagnosis of a complex renal cyst and to collect clinical data. Cases were categorized according to a modification of the Bosniak classification, using ultrasound in most patients and computerized tomography or magnetic resonance imaging when available.
Results: Complex renal cysts were identified in 39 children.