From our study it seems that regardless of upregulation or downre

From our study it seems that regardless of upregulation or downregulation of these functional genes, the trend of the tumor is to deteriorate due to the abnormal expression of genes mediated by HIF-1alpha. Our work aims to find more novel functional genes whose expression is mediated by HIF-1alpha

to support the development of new therapeutic targets for gene targeted therapy of SCLC. Acknowledgements This work was supported by the Key Basic Scientific Research Program of Shanghai City (No.04BA05). We would like to thank the studies center of Xin Hua Hospital for providing technical assistance and professor Hong-Sheng Zhu for critical reading of the manuscript. References 1. Vaupel P, Kallinowski F, Okunieff P: Blood

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