Hypertension that developed after nephrectomy was not an exclusion criterion. Of 282 patients who donated between 1986 and 2000, 69 donors could not be contacted.

Sixty-nine donors were older than 65 years, 6 had diabetes mellitus, 1 had a history of coronary artery disease, 4 had malignancy and 5 had documented hypertension before nephrectomy, leaving 101 patients for comparison with the control group. Patients had to be at least 12 months post-nephrectomy and the median time post-donation was 5 years. The mean GFR of kidney donors was 75 mL/min, which was approximately 25 mL/min per Cobimetinib chemical structure 1.73 m2 (0.42 mL/min per 1.73 m2) less than that of controls. The frequency of CAC and mean calcification scores were similar for kidney donors (13.9%; 4.5 ± 22.6) and controls (17.2%; 13.2 ± 89.2). CAC was not associated with decreased GFR, and the correlation between CAC and GFR was not statistically significant. Kidney donors with calcification were more likely to be older (P = 0.003)

and male (P = 0.001). Age- and sex-adjusted analysis showed an association between greater parathyroid hormone (PTH) levels (odds ratio 1.023; 95% CI: 1.001–1.045; P = 0.037) and CAC in kidney donors.25 Recognizing that a fixed lower limit of GFR does not find more adequately define donor acceptability (probably too low for young donors and too high for older donors), Thiel and colleagues developed calculations taking into account the life expectancy

of the donor – the Minimum Creatinine Clearance.8 Discussions with nephrologists and gerontologists in Switzerland led them to define a creatinine clearance (CrCl) of 40 mL/min at age 80 years as adequate to maintain fluid and electrolyte homeostasis in the donor as well as maintaining adequate levels of erythropoietin and active Vitamin D. A second calculation was made targeting a CrCl of at least 30 mL/min per 1.73 m2 at age 80 years as the absolute minimum acceptable for an elderly person (but possibly requiring some intervention MG-132 ic50 to maintain normal, age-related quality of life). Using such a formula, a 30-year-old donor may require a CrCl of 123 mL/min per 1.73 m2 while the level for a 70-year-old may be of the order of 68 mL/min per 1.73 m2. Most of the evidence relating to renal function in living donors comes from retrospective cohort studies commonly of small size and with poor follow up (see Table 1). There is a lack of prospective long-term data regarding live donor renal function following donation, particularly in relation to consequences of donation in certain donor subgroups such as those with reduced GFR.