I. The producing organism and biological activity. Torin 1 manufacturer J Antibiot (Tokyo) 1996,49(3):253–259.CrossRef 56. Huang X, Roemer E, Sattler I, Moellmann U, Christner A, Grabley S: Lydiamycins A-D: cyclodepsipetides with antimycobacterial properties. Angew Chem

Int Ed Engl 2006,45(19):3067–3072.PubMedCrossRef 57. Miller ED, Kauffman CA, Jensen PR, Fenical W: Piperazimycins: cytotoxic hexadepsipeptides from a marine-derived bacterium of the genus Streptomyces. J Org Chem 2007,72(2):323–330.PubMedCrossRef 58. Fehr T, Kallen J, Oberer L, Sanglier JJ, Schilling W: Sanglifehrins A, B, C and D, novel cyclophilin-binding compounds isolated from Streptomyces sp. A92–308110. II. Structure elucidation, stereochemistry and physico-chemical properties. J Antibiot (Tokyo) 1999,52(5):474–479.CrossRef 59. Zhang H, Chen J, Wang H, Xie Y, Ju J, Yan Y: Structural analysis of HmtT and HmtN involved in the tailoring steps of himastatin biosynthesis. FEBS Lett 2013,587(11):1675–1680.PubMedCrossRef 60. Huang T, Wang Y, Yin J, Du Y, Tao M, Xu J, Chen W, Lin S, Deng Z: Identification and characterization of the pyridomycin biosynthetic

gene cluster of Streptomyces pyridomyceticus NRRL B-2517. J Biol Chem 2011,286(23):20648–20657.PubMedCentralPubMedCrossRef 61. Ishikawa J, Hotta K: FramePlot: a new implementation of the frame analysis for predicting protein-coding regions in bacterial DNA with a high G + C content. GPCR Compound Library in vivo FEMS Microbiol Lett 1999,174(2):251–253.PubMedCrossRef 62. Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ: Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 1997,25(17):3389–3402.PubMedCentralPubMedCrossRef

63. Ansari MZ, Yadav G, Gokhale RS, Mohanty D: NRPS-PKS: a knowledge-based resource for analysis of NRPS/PKS megasynthases. Nucleic Acids Res 2004,32(Web Server issue):W405-W413.PubMedCentralPubMedCrossRef 64. Rausch C, Weber T, Kohlbacher O, Wohlleben W, Huson DH: Specificity prediction of adenylation domains in nonribosomal peptide synthetases (NRPS) using transductive support vector machines (TSVMs). Nucleic Acids Res 2005,33(18):5799–5808.PubMedCentralPubMedCrossRef 65. Gust BKT, Chater K: PCR targeting system in Streptomyces Fossariinae coelicolor A3(2). Norwich U K: The John Innes Foundation; 2002. Competing interests The authors declare that they have no competing interests. Authors’ contributions SL designed this study; YD, YW, TH performed the experiments; YD, MT, ZD and SL analyzed data; YD and SL wrote this manuscript; MT and ZD edited this manuscript; All authors read and approved the final manuscript.”
“Background Mycoplasma pnuemoniae (M. pneumoniae) belongs to the class of the Mollicutes and is one of the smallest free-living organisms. It is a major cause of community-acquired pneumonia (CAP) worldwide in all age groups, and can also induce manifestations in extrapulmonary sites involving almost all organs of the human body [1, 2]. With the exception of M.