In dogs, A beta 1-37 was significantly increased in response to treatment with the gamma-secretase modulator E2012. Conclusions: The results presented add to the current knowledge on APP processing and that A beta isoforms can be used as novel biomarkers to monitor anti-A beta treatments in clinical trials and may be valuable for making a go/no go decision for large and expensive phase 2 or 3 clinical trials. Copyright (C) 2012 S. Karger AG, Basel”
“Tobacco is a very abundant bio-based resource in nature, and large amounts of tobacco residues are produced from the cigarette industry, which can be exploited and utilized for energy. In this work, the pyrolysis of
tobacco residues including stems and leaves was analyzed by a learn more Thermogravimetric Analysis (TGA) instrument and the corresponding derivative thermogravimetric analysis (DTG). The TGA curves were obtained at the heating STI571 concentration rate of 10 degrees C/min and with temperature range from 25 degrees C to 700 degrees C. The results indicated that the pyrolysis of tobacco stems and tobacco leaves included three stages: dehydration, main devolatilization, and continuous devolatilization. More importantly, between the temperature range of 200 degrees C and 350 degrees C, by using the Coats-Redfern
equation, correlation coefficients of different reaction models describing the pyrolysis of tobacco stems and leaves were predicted, and the best-fit models for different MEK162 stages of pyrolysis were found. The activation energies as well as frequency factors (A) from the best-fit models were calculated. (C) 2012 Elsevier B.V. All rights reserved.”
“Treatment of 2-X-substituted pyrazines [X = H, Me, Et, Pr, i-Pr, t-Bu, MeCH(OH), H2N, AcNH] with O-mesitylenesulfonylhydroxylamine gave the corresponding 2-X- and 3-X-(1-amino)pyrazin-1-ium mesitylenesulfonates. 2-Alkylpyrazines (X = Me, Et, Pr, i-Pr) displayed a correlation between the
logarithms of the concentration ratio of 2- and 3-substituted cations and substituent steric constants. Wider series of substituted pyrazines [X = H, Me, Et, Pr, i-Pr, MeCH(OH), H2N, AcNH] conformed to a multiparameter correlation between the logarithms of the concentration ratio of 2- and 3-substituted cations, on the one hand, and substituent constants sigma(I), sigma (R) (o) , and E (s) (o) , on the other. The obtained data on the regioselectivity of amination of pyrazines were interpreted in terms of DFT/PBE/3Z quantum-chemical calculations.”
“Intra-articular tumors and tumor-like conditions of the hip are rare. When they occur, they can interrupt normal articular congruency, leading to pain and joint dysfunction. If these conditions result in large osteochondral defects, they pose challenging reconstructive problems in young patients. We describe a case of a 29-year-old man who presented with a 2-year history of right hip pain.