International Journal of Sport and Health Science 2006, 4:86–94 C

International Journal of Sport and Health Science 2006, 4:86–94.CrossRef 28. Derave W, Ozdemir MS, Harris RC, Pottier A, Reyngoudt H, Koppo K, Wise JA, Achten E: beta-Alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction

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Ipatasertib price 72:607S-617S.PubMed Competing interests The authors declare that they have no competing interests. Authors’ contributions TM is the principal investigator of the project. MS, HM, YT and FM designed the study; MS and HM collected the data; YT and FM conducted data analysis; TM, MS and HM wrote the manuscript. All authors have selleck read and approved the final manuscript.”
“Background The use of nutritional supplements has exponentially increased in the past decade [1–3]. In particular, supplements containing L-arginine are extremely popular among healthy people engaging in resistance training exercises [4, 5]. Generally, these supplements are marketed as nitric oxide stimulators, which purpose to increase muscular strength and endurance as potential benefits to the user. The premise

of these claims are that they increase the availability of arginine in the system, thus augmenting synthesis of nitric oxide release by way of the enzyme nitric oxide synthase [4, 6, 7]. It is believed that this increase in nitric oxide will allow for improved blood flow [8, 9] and this could potentially be beneficial for individuals performing resistance exercises. Further, an elevation in blood flow could theoretically improve exercise performance by increasing nutrient delivery and/or waste-product removal from exercising skeletal muscles [10–12]. It should be noted PIK3C2G that concentrations of L-arginine in the body can be the rate limiting step for nitric oxide production [7, 13, 14]. However, there is still no clear evidence to conclude L-arginines role as a nitric oxide stimulator that improves resistance exercise performance in healthy adults [4]. Recently, commercially available L-arginine supplements have been combined with alpha ketoglutarate, in an effort to further improve exercise performance by increasing adenosine triphosphate production through the electron transport chain [15]. Specifically, alpha ketoglutarate is a metabolite produced by the oxidative decarboxylation of isocitrate; a process that occurs in the Krebs cycle [13, 16].

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