Methods: A retrospective review was performed of all coagulopathic patients (international normalized ration >1.5 or platelets <100,000 per mu L) admitted for at least 72 hours to the surgical PARP inhibitor intensive care units of a tertiary care center between January 2008 and January 2009. Patients were divided into
two groups based on providing (group 1) or withholding (group 2) chemical prophylaxis. The incidence of VTE was then compared between the two groups.
Results: A total of 513 patients were included in the study: 241 patients in group 1 and 272 patients in group 2. The overall incidence of VTE was 16.4%. The incidence of VTE in the patients who received chemical prophylaxis was 17.0%, whereas the incidence in patients without chemical prophylaxis was 15.8% (p = 0.72).
Conclusion: Coagulopathic critically ill surgical patients remain at significant risk for VTE. Unfortunately, chemical VTE prophylaxis does not seem to decrease this risk. Further research is warranted to investigate the nature of this increased risk of VTE and the reason chemical VTE prophylaxis
has no benefit.”
“Radiation therapy is a critical component of the multidisciplinary management of invasive breast cancer. In appropriately selected patients, radiation not only improves local control, sparing patients the morbidity check details and distress of local recurrence, but it also improves survival by preventing seeding and reseeding of distant metastases from persistent reservoirs of locoregional disease. In recent years, considerable progress has been made toward improving our ability to select patients most likely to benefit from radiotherapy and to administer treatment in ways that maximize clinical benefit while minimizing toxicity and burden. This article reviews the role of radiation therapy in invasive breast cancer management, both after
breast-conserving surgery and after mastectomy. It focuses particularly on emerging evidence that helps to define the clinical situations in which radiotherapy is indicated, the Flavopiridol concentration appropriate targets of treatment, and optimal approaches for minimizing both the toxicity and the burden of treatment, all in the context of the evolving surgical and systemic management of this common disease. It includes a discussion of new approaches in breast cancer radiotherapy, including hypofractionation and intensity modulation, as well as a discussion of promising avenues for future research. CA Cancer J Clin 2014;64:135-152. ((c)) 2013 American Cancer Society.”
“The thermal behavior of two wood species treated with ionic liquid, 1-butyl-3-methylimidazolium tetrafluoroborate, was investigated using thermogravimetry/differential scanning calorimetry/Fourier transform infrared spectroscopy/mass spectrometry coupled methods in order to elucidate the ionic liquid effect on the wood thermal behavior. It was pointed out that the ionic liquid-treated wood samples show degradation in two processes.