Nevertheless, the clinical management of sinonasal cancer has improved owing to advances in imaging techniques, endoscopic surgical approaches, and radiotherapy. Genetic profiling and the development of in vitro cell lines and animal models currently form the basis for future targeted anticancer therapies. We review these advances in our understanding and treatment of sinonasal tumours.”
“Background: Allergic rhino-conjunctivitis (ARC) and allergic rhinitis are inflammatory diseases that develop through immunoglobulin E in the rhino-ocular
mucosa due to allergy. The main symptoms are runny nose, nasal congestion, sneezing, itchy nose, and conjunctivitis. Objective: This study was designed to evaluate plasma 25-hydroxyvitamin D levels in patients with ARC. Study design: This study was planned as a prospective and cross sectional study. This study was performed in a tertiary referral center. Methods: This observational study involved 42 patients click here with ARC and 35 consecutive, age-and sex-matched healthy subjects. Patients in both groups underwent skin-prick test. Plasma 25-hydroxyvitamin D levels of all subjects
were quantified with electrochemiluminescence technique. Results were compared between the groups and p smaller than 0.05 was considered as statistically significant. Results: Group one included 42 ARC patients (15 male, 27 female, ages between 12 and 43, average age 25.7 +/- 8.6); group two included 35 healthy people (15 male, 20 female, ages between 12 and 44, average age 26.9 +/- 9.1). Plasma 25-hydroxyvitamin MK-8931 clinical trial D levels of the subjects with ARC group (7.33 +/- 3.61 ng/mL, standard error mean: 0.55, range 3.17-13.68 ng/mL) were significantly lower than the control group (13.37 +/- 5.42 ng/mL, standard error mean: 0.91, range 6.84-25.92 ng/mL) (p = 0.010, Independent-Samples test). Conclusions: We found lower plasma
vitamin D levels in patients with ARC when compared with the control group.”
“A major concern in mandibular advancement surgery using bilateral sagittal split osteotomies (BSSO) is potential postoperative relapse. Although the role of postoperative changes in condylar morphology on skeletal relapse was reported in previous studies, no study so far has objectified the precise changes of the condylar volume. The aim of the present study was to quantify the postoperative signaling pathway volume changes of condyles and its role on skeletal stability following BSSO mandibular advancement surgery. A total of 56 patients with mandibular hypoplasia who underwent BSSO advancement surgery were prospectively enrolled into the study. A cone beam computed tomography (CBCT) scan was acquired preoperatively, at 1 week postoperatively and at 1 year postoperatively. After the segmentation of the facial skeleton and condyles, three-dimensional cephalometry and condylar volume analysis were performed. The mean mandibular advancement was 4.