Rapamy cin was initated at two mg every day and was titrated to a plasma level of four 12 Mg/ml. A therapy cycle was defined as four weeks. Individuals had been evaluated at eight week intervals with laboratory information and brain imaging. Patients remained on treatment until tumor progression, unacceptable toxicity, or patient selleck with drawal occurred. A total of 21 individuals have been screened for enrollment, and 18 patients had been evaluable. The indicate age was 51. six many years. Thirteen patients have been men. 6 individuals had biopsy only, two individuals had subtotal resections, and ten individuals had gross complete resections. The indicate KPS was 77%. One particular patient experienced grade III rash. A second patient seasoned grade III diarrhea, grade III renal failure, grade IV hypotension, grade IV dyspnea, grade IV metabolic acidosis, grade III coagulopathy. A third patient expe rienced grade III wound infection requiring debridement and antibiotics.
A fourth patient expert grade III elevated LFT, intratumoral hemor rhage, seizure, and hypertension. The fee of 6 month progression cost-free sur vival was 16. 6%. The indicate time for you to tumor progression was three months, and there have been 2 minor responses. Gefitinib plus rapamycin for patients with recurrent glioblastoma is properly tolerated within a vast majority of individuals handled. The mixture PIK-75 solubility made two small responses and conferred condition stabil ity inside a considerable percentage of individuals. TA 03. RECURRENCE OF BRAIN TUMORS May well BE PREVENTED WITH RUTA AND CALCAREA PHOSPHORICA Prasanta Banerji and Pratip Banerji, PBH Analysis Basis, Kolkata, India The recurrence of brain tumors right after surgery, radiation therapy, and chemotherapy is often a widespread predicament, while a lot of typical and alter native therapies can be found.
The usage of Ruta six and Calcarea Phosphorica 3X to treat brain tumors has gained acceptance in India, and most of our patients are undergoing this treatment method with out any

other form of conven tional therapy. In other countries, however, this remedy is used mainly to prevent tumor recurrence. We analyzed the records of sufferers who underwent our remedy devoid of undergoing any concurrent standard treatment to prevent tumor recurrence only. The analysis showed that our treatment method has a definite role in preventing the recurrence of brain tumors, 66. 7% of the cases studied did not have recurrence. Prevention in oligodendroglioma was excellent but was comparatively less so in brainstem gliomas. TA 04. SWOG S0001, A PHASE III STUDY OF RADIATION Therapy AND O6 BENZYLGUANINE PLUS BCNU VERSUS RT AND BCNU ALONE FOR NEWLY DIAGNOSED GLIOBLASTOMA MULTIFORME AND GLIOSARCOMA D. T. Blumenthal,one,2 C. Rankin,3 K. Stelzer,4 S. Schulman,5 A. Sloan,6 E. Rushing,7 L. Gavigan,eight and A.