Six of 13 postpartum NC women brought their children and nursed them on test nights; two others pumped their breasts but did not nurse children in the GCRC. Statistical analyses of total sleep time, sleep latency, sleep efficiency, and wake after sleep onset showed no significant differences between NC and DP groups as a function of breastfeeding status, child’s

presence in the room, or their interaction. Inhibitors,research,lifescience,medical Table I Distribution of age ranges and mean (SD), Structured Interview Guide for the Hamilton Depression Rating Scale, Seasonal. Effects of reproductive status and diagnosis on polysomnographic measures (with age as a covariate) The omnibus MANOVA (without covariate) was highly significant for RS (P<.00001) but was non-significant for diagnosis (P=.364) and the RS x diagnosis interaction (P=.811). Univariate ANOVA showed significant effects of RS in 11 of the 14 PSG variables examined. However, the covariate of age was correlated to a substantial degree (P<.10, at least) in five of the Inhibitors,research,lifescience,medical PSG measures, and after including age as a covariate in the analyses, significant main effects of RS were obtained

for SE (P=.027), SL (P=.041), S1 % (P=.008), S3% (P=.0001), SWS % (P=.0001), and REM density (P.020) (Table II). Pair-wise comparisons of age-adjusted significant values Inhibitors,research,lifescience,medical (with Bonferroni correction) are displayed in Figure 1. Figure 1. Mean + SEM polysomnography (PSG) measures as a function of reproductive status. P-values denote Bonferroni-adjusted significance Inhibitors,research,lifescience,medical of differences from menstrual mean (A – D) or postpartum mean (E). Table II ATM Kinase Inhibitor manufacturer F-ratios and P-values for analyses of effects of reproductive status (RS: menstrual vs pregnant vs postpartum vs menopausal) and age category (19-27, 28-36, 37-45, 46+) on polysomnographic (PSG) variables, covariate adjustment was applied when the covariate … We found only

one significant mood-related effect: REM percentage was significantly greater in Inhibitors,research,lifescience,medical DP vs NC across RS groups (Group means + SEM = 22.3+0.9 vs 19.6+0.8%, F(1,130) = 5.335, P .022) as illustrated in Figure 2. Figure 2. Mean + SEM REM percentage TCL in norma! controls and depressed patients as a function of reproductive status. Effects of age category and diagnosis on polysomnographic measures (with reproductive status as a covariate) The omnibus MANOVA (without covariate) was significant for age category (P<.00001) but was non-significant for diagnosis (P=.127) and the age category x diagnosis interaction (p = .728). Univariate ANOVA showed significant effects of age category in 8 of the 14 PSG variables examined. However, RS was correlated with four of the PSG measures to a substantial degree (P< .10, at least), and after including RS as a covariate in the analyses, significant main effects of age category were obtained for TST (P=.001), SL (P=.037), S2 % (P=.019), S3 % (P=.001), S4% (P=. 0001), and SWS % (P=.0001) (Table II).