The structures of the new metabolites were characterised by spectroscopic analysis and chemical degradation. Of the new compounds isolated, alterporriol F was highly cytotoxic towards HeLa and KB cells, with IC50 values of 6.5 and 7.0 mu g mL-1.”
“Background: The basic life support (BLS) termination of resuscitation (TOR) rule recommends transport and continued resuscitation when cardiac arrest is witnessed by EMT-Ds, or there is a return of spontaneous circulation, or a shock is given, and prior studies

have suggested the transport rate should fall to 37%.

Methods and results: This real-time prospective multi-center implementation trial evaluated the selleck BLS TOR rule for compliance, transport rate and provider and physician comfort. Both provider and physician noted their decision-making rationale and ranked their comfort on a 5-point Likert scale. Functional survival was measured

at discharge. Of 2421 cardiac arrests, NCT-501 mouse 953 patients were eligible for the rule, which was applied correctly for 755 patients (79%) of which 388 were terminated. 565 patients were transported resulting in a reduction of the transport rate from 100% (historical control) to 59% (p < 0.001). The BLS TOR rule was not followed in 198 eligible patients (21%) and they were all transported despite meeting the criteria to terminate. Providers cited 241 reasons for non-compliance: family distress, short transport time interval, younger age and public venue. All 198 transported patients, non-compliant with the rule, died. Both providers and physicians were comfortable with using the rule to guide TOR (median [IQR] of 5 [4,5]; p < 0.001).

Conclusions:

This implementation Ulixertinib concentration trial confirmed the accuracy of the BLS TOR rule in identifying futile out-of-hospital cardiac arrest (OHCA) resuscitations, significantly reduced the transport rate of futile OHCA and most providers and physicians were comfortable following the rule’s recommendations. (C) 2013 Elsevier Ireland Ltd. All rights reserved.”
“Objective: To use statistical and root cause analysis to clarify relationships between labeling errors and causal factors in an anatomic pathology gross room and to identify potential solutions.

Methods: Retrospective analysis was performed on quality-assurance records of Associated Regional and University Pathologists (ARUP) Laboratories/University of Utah Department of Pathology between July 2009 and April 2011.

Results: Eighty-five errors had occurred among the 45,000 cases processed over the study period. A total of 27.0% of errors were committed by residents, although they processed only 5.5% of cases. Errors were associated with case complexity. Root cause analysis identified the mechanical cassette labeler, the size and layout of the gross room, and process standardization as areas requiring improvement.