Baseline functional measures were assessed with the Sexual Health Inventory for Men and International Prostate Symptom Score. Questionnaires were administered a median of 11.1 months (IQR 4.6-26.1) after surgery. Clinicopathological, perioperative and functional outcomes were analyzed with univariable and multivariable models to examine associations with patient decisional regret.

Results: Of the patients 88% did not regret the decision to undergo robot-assisted laparoscopic prostatectomy. Baseline health related quality of life, specifically baseline incontinence and superior erectile function, independently

predicted increased postoperative decisional regret. In addition, older age, postoperative incontinence measured by pad

use, postoperative erectile dysfunction and Selleckchem GSK2118436 longer time from surgery were independent predictors of increased decisional regret. Preoperative cancer risk, and histopathological and short-term biochemical outcomes were unrelated to AZD9291 manufacturer decisional regret.

Conclusions: Decisional regret following robot-assisted laparoscopic prostatectomy is independently predicted by age, baseline urinary and erectile function, perioperative outcomes, and postoperative urinary and erectile function. These results may be useful to urologists during preoperative patient counseling to set realistic expectations for the postoperative course, potentially improving the surgical experience.”
“Pancreatic exocrine insufficiency and a reduction in the volume of the pancreas on computed tomography developed in two patients after more than 24 months of sorafenib found therapy.To the Editor: Sorafenib is an oral multitargeted tyrosine kinase inhibitor with

potent antiangiogenic activity. It was first approved to treat renal-cell carcinoma,(1) but it is also active in other solid tumors, such as hepatocellular and thyroid carcinomas. Prolonged use of sorafenib may cause cumulative, serious, and life-threatening late toxic effects due to the long-term effect of antiangiogenic therapies on the microvessels. We report reproducible evidence of irreversible pancreatic atrophy in two patients after long-term treatment with sorafenib. The first patient received sorafenib for 2.5 years; during the treatment period, the patient had a complete tumor response for 1 year. …”
“Background. Social dysfunction is a hallmark symptom of schizophrenia which commonly precedes the onset of psychosis. It is unclear if social symptoms in clinical high-risk patients reflect depressive symptoms or are a manifestation of negative symptoms.

Method. We compared social function scores on the Social Adjustment Scale-Self Report between 56 young people (aged 13-27 years) at clinical high risk for psychosis and 22 healthy controls.