The participant has to decide whether to accept the offer of a share of resources made by the individual. This can be fair (eg, making a 50:50 split on $20 so each gains $10) or progressively unfair (eg, only $4 is offered to the participant). Individuals with psychopathy show increased rejection of unfair offers, even at cost to themselves, relative to comparison individuals41 (d) Moral judgment: Individuals with psychopathy Inhibitors,research,lifescience,medical show

reduced responsiveness to what can be termed “care-based” transgressions (ie, transgressions involving harm to another; eg, one person hitting another10). This has been seen using a variety of paradigms.18,42-45 Again this impairment

in transgression processing is selective. buy BKM120 Care-based transgressions are reliant on appropriate responsiveness to the pain and distress of others.10 As noted above, this is dysfunctional in adults Inhibitors,research,lifescience,medical with psychopathy.32-36 In contrast, conventional transgressions (reliant on authority; eg, talking in class) are reliant on appropriate responsiveness to other individual’s anger Inhibitors,research,lifescience,medical while disgust-based transgressions (that can cover aspects of sexual behavior) are reliant on appropriate responsiveness of other individual’s disgust.10) Adults with psychopathy show intact processing of these emotional expressions.35,36 They also show intact processing of these forms of transgression.18,42-44 Given these data, a variety of authors have suggested that an emotional dysfunction underpins the

deficits seen in individuals with psychopathy.18,19,28,46-49 Inhibitors,research,lifescience,medical The oldest of these positions suggested that punishment processing was dysfunctional while reward processing was intact or even possibly superior. 18,28,46-48 Inhibitors,research,lifescience,medical It is now clear that the situation is considerably more complicated.10 Three critical data points are important to note. First, the expression oxyclozanide impairment is not seen for all aversive expressions; it is seen for fear and sadness but not anger and disgust. This is inconsistent with a general impairment in processing aversive stimuli. Second, the expression processing impairment is also seen for happy expressions. This suggests that the processing of rewarded stimuli is also disrupted. Third, the immediate response to punishment is intact in adults with psychopathy. To consider the last point in more detail, when the participant is punished on a task such as the reversal learning paradigm, they are likely to change their response on the next trial. If this new response is then rewarded, they are more likely to stay with the new response.