[19�C30] Dasatinib cost HPTLC remains one of the most flexible, reliable, and cost-efficient separation technique ideally suited for the analysis of botanicals and herbal drugs. Used with standardized procedures, it guarantees reproducible results, a vital element in the routine identification of complex fingerprints of plant extracts and pharmaceutical products. It has established itself as the method of choice for handling complex analytical tasks involving herbal drugs and botanicals. The unique combination of state-of-art instrumentation, standardized procedures, and solid theoretical foundations enables it to deliver reliable, cGMP-compliant results time after time. High-throughput analysis using HPLTC is being aimed at the rapid analysis of large numbers of compounds.
This field has been expedited by the requirement to provide analytical support for multiple drug targets emerging from the field of molecular biology, human genetics, and functional genomics. Further, drivers for development have been in the support for the analysis of large compound libraries arising from parallel and combinatorial chemistry, and economic pressure to reduce time-to-market for new drug candidates. APPLICATIONS OF HPLTC HPTLC is one of the most widely applied methods for the analysis in pharmaceutical industries, clinical chemistry, forensic chemistry, biochemistry, cosmetology, food and drug analysis, environmental analysis, and other areas. It is due to its numerous advantages, for example, it is the only chromatographic method offering the option of presenting the results as an image.
Other advantages include simplicity, low costs, parallel analysis of samples, high sample capacity, rapidly obtained results, and possibility of multiple detection. Le Roux et al evaluated a HPTLC technique for the determination of salbutamol serum levels in clinical trials and established as a suitable method for analyzing samples from the serum. Many lipids have also been analyzed and studied using HPTLC; 20 different lipid subclasses were separated using HPTLC with the reproducible and promising results. Many reports on studies related to clinical medicine have already been published in many journals. HPTLC is now strongly recommended in the analysis of drugs in serum and other tissues. HPTLC IN PHARMACEUTICAL PRODUCTS HPTLC is also used in analyzing the purity and efficacy of many pharmaceutical preparations and dosage forms.
Puranik et al developed and validated a simple, rapid, and accurate chromatographic methods (HPLC and HPTLC) for simultaneous determination Drug_discovery of ofloxacin and ornidazole in solid dosage form. The amount of ofloxacin and ornidazole estimated as percentage of label claimed was found to be 100.23 and 99.61% with mean percent recoveries 100.47 and 99.32%, respectively.